Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone

Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone Descriptor: Aldo-keto reductase family 1 member C1, BETA-MERCAPTOETHANOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Couture, J.F, Legrand, P, Cantin, L, Luu-The, V, Labrie, F, Breton, R. Deposit date: 2002-09-18 Release date: 2003-09-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. J.Mol.Biol., 331, 2003人源20α-羟基类固醇脱氢酶（20alpha-HSD）与烟酰胺腺嘌呤二核苷酸磷酸（NADP）及20α-羟基孕酮形成三元复合物的晶体结构。描述项：醛酮还原酶家族1成员C1、β-巯基乙醇、烟酰胺腺嘌呤二核苷酸磷酸（NADP）……。作者：Couture, J.F.、Legrand, P.、Cantin, L.、Luu-The, V.、Labrie, F.、Breton, R.。提交日期：2002年9月18日；发布日期：2003年9月30日；最后修改日期：2024年2月14日。实验方法：X射线衍射（分辨率1.59埃）。引用文献：《人源20α-羟基类固醇脱氢酶：晶体学与定点诱变研究揭示C21类固醇的新型结合位点》，《Journal of Molecular Biology》，331卷，2003年