Baicalein-loaded chitosan films for local treatment of oral infections

Dissolution.xlsx - data represent the percentage of baicalein released. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. Dissolution studies of electrospun nanofibers were performed using an Agilent 708-DS dissolution apparatus. A standard basket method was used at 37 ± 0.5 °C with a stirring speed of 50 rpm. Systems were placed in 200 mL of artificial saliva solution at pH 6.8 (potassium chloride (1.20 g), sodium chloride (0.85 g), di-potassium hydrogen orthophosphate (0.35 g), magnesium chloride (0.05 g), calcium chloride (0.20 g), xylitol (20.0 g) and water up to 1 L; pH was adjusted to 6.8 by 1 M HCl). The liquid samples were collected at specified time intervals, and an equal volume of temperature-equilibrated media was replaced. The samples were filtered through a 0.45 μm nylon membrane filter. The concentration was determined using the HPLC method (https://www.mdpi.com/2073-4360/17/16/2167) and converted, relative to the weight, into the percentage of the substance released during the experiment.