T-cell receptor repertoire sequencing associated with lymph node metastasis in colorectal cancer

These data aimed to investigate the T-cell receptor (TCR) repertoire of CRC patients with and without LN metastasis to identify potential biomarkers for metastasis prediction. Our results revealed that patients with LN metastasis exhibited a significantly higher number of V-J combinations and immune CDR3 sequences relative to control patients. Taken together, these findings suggest that the TCR repertoire is altered in CRC patients with LN metastasis, and indicates that they may play a role in disease progression.