PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12

Ubiquitinated PEX5 isoform S or isoform L (Ub:PEX5S,L) is released from the peroxisomal membrane and interaction with the Docking and Translocation Module by PEX1:PEX6:PEX26:ZFAND6 (the peroxisomal AAA ATPase complex, receptor export module) (Tamura et al. 2014, Law et al. 2017, also inferred from yeast homologs). PEX1 and PEX6 form a cytosolic hexameric ring that is anchored to the peroxisomal membrane by PEX26. Hydrolysis of ATP by PEX1 and PEX6 appears to cause a conformational change in PEX1:PEX6:PEX26:ZFAND6 that releases Ub:PEX5S,L from the peroxisomal membrane and into the cytosol (reviewed in Saffert et al. 2017).

泛素化PEX5异构体S或异构体L（Ub:PEX5S,L）自过氧化物酶体膜释放，并与由PEX1:PEX6:PEX26:ZFAND6（过氧化物酶体AAA ATP酶复合物，受体输出模块）介导的停靠和转运模块相互作用（参见Tamura等，2014年，Law等，2017年，亦从酵母同源物中推断）。PEX1和PEX6形成一个锚定于过氧化物酶体膜的细胞质六聚环。PEX1和PEX6对ATP的水解似乎导致PEX1:PEX6:PEX26:ZFAND6复合物的构象变化，从而将Ub:PEX5S,L从过氧化物酶体膜释放到细胞质中（参见Saffert等，2017年的综述）。