Independent SNPs associated with TSH and FT4 serum levels.

The table shows the association results for SNPs that reached genome-wide level (p<5×10−08) in the main meta-analysis. SNPs at LPCAT2/CAPNS2 and NETO1/FBXO15 reached the GW threshold in the gender-specific meta analysis (see Table 3), and here the p-value in the main meta-analysis is reported. For each SNP, the best candidate gene is showed, as well as its genomic position in build 36, the effect allele (A1) and the other allele (A2), its combined frequency across studies and its standard error, the effect size and its standard error, the p-value for association, the number of samples analyzed, and the p-values for heterogeneity of effects across the cohorts meta-analyzed. Effect sizes are standardized, so they represent the estimated phenotypic change, per each copy of the effect allele, in standard deviation units.