Carcinogenic Potency Database (CPDB)

Carcinogenic Potency Database (CPDB) is a single standardized resource of the results of 45 years of chronic, long-term carcinogenesis bioassays. The experiments vary widely in design, histopathological examination and nomenclature, and in the published authors’ choices of what information to publish in their papers. Data are included from 6153 experiments reported in the general literature and in the in Technical Reports of the National Cancer Institute/National Toxicology Program (NCI/NTP). Information is given in the CPDB on strain, sex, route of compound administration, target organ, histopathology, author’s opinion about carcinogenicity, and reference to the published paper, as well as quantitative data on statistical significance, tumor incidence, dose-response curve shape, length of experiment, duration of dosing, and dose-rate. The files on this Web site for the Excel format include (A) documentation of methods, field descriptions, and linking instructions; (B) Excel files; and (C) ancillary files of appendices. NOTE: This dataset is no-longer updated with new content.

致癌性效力数据库（Carcinogenic Potency Database，CPDB）是一项标准化单一资源，整合了45年以来慢性长期致癌性生物检测实验的结果。此类实验在实验设计、组织病理学检查方法与术语命名规范，以及作者发表论文时选择披露的信息范畴上均存在显著差异。本数据库收录的实验数据源自6153项刊载于公开学术文献，以及美国国家癌症研究所/国家毒理学计划（National Cancer Institute/National Toxicology Program，NCI/NTP）技术报告中的实验。CPDB中收录的信息包括实验动物品系、受试动物性别、受试化合物给药途径、靶器官、组织病理学特征、作者对受试物致癌性的判定意见，以及相关论文的参考文献；同时还包含统计学显著性水平、肿瘤发生率、剂量-反应曲线形态、实验总时长、给药持续时长以及给药速率的量化数据。本网站提供的Excel格式文件包含三类内容：(A) 实验方法文档、数据字段说明与数据关联指引；(B) Excel数据表文件；(C) 附录配套辅助文件。注意：本数据集现已停止更新，不再新增任何内容。

搜集汇总

背景与挑战

背景概述

Carcinogenic Potency Database (CPDB) 是一个标准化的致癌性数据库，汇总了45年来6153个慢性长期致癌性生物测定的实验数据，涵盖实验设计、病理学评估和定量统计信息。该数据集整合了来自一般文献和NCI/NTP技术报告的广泛研究，但目前已不再更新新内容。