Systemic RNA interference-defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans

To investigate mutations in genes involved in the cellular import of dsRNA neuroprotection, we generated a profile of individual genes affected when dsRNA transport is incapacitated and established a foundation for the systemic analysis of their distinct contributions to neuroprotection. We then identified a set of previously unreported neuroprotective proteins using data obtained from RNA-seq. Comparative gene expression profiling analysis of RNA-seq data for C. elegans in an a-synuclein background with and without the sid-1 mutation, 3 biological replicates.