Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide.

Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide. Descriptor: (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Vieira, D.F, Calvet, C.M, Choi, J.Y, Cameron, M.D, Gut, J, Kellar, D, Siqueira-Neto, J.L, McKerrow, J.H, Roush, W.R, Podust, L.M. Deposit date: 2013-08-16 Release date: 2014-09-03 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Binding Mode and Potency of N-Indolyl-Oxopyridinyl-4-Amino-Propanyl-Based Inhibitors Targeting Trypanosoma Cruzi Cyp51 J.Med.Chem., 57, 2014

克氏锥虫（Trypanosoma cruzi）CYP51与抑制剂(R)-N-(3-(1H-吲哚-3-基)-1-氧代-1-(吡啶-4-基氨基)丙-2-基)-4-(4-(4-氯苯基)哌嗪-1-基)-2-氟苯甲酰胺结合的晶体结构。描述符：(R)-N-(3-(1H-吲哚-3-基)-1-氧代-1-(吡啶-4-基氨基)丙-2-基)-4-(4-(4-氯苯基)哌嗪-1-基)-2-氟苯甲酰胺、1,2-乙二醇（1,2-ETHANEDIOL）、氯离子（CHLORIDE ION）等。作者：Vieira, D.F、Calvet, C.M、Choi, J.Y、Cameron, M.D、Gut, J、Kellar, D、Siqueira-Neto, J.L、McKerrow, J.H、Roush, W.R、Podust, L.M。沉积日期：2013-08-16；发布日期：2014-09-03；最后修改日期：2023-12-20。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.03埃（Å）。引用：靶向克氏锥虫Cyp51的N-吲哚基-氧代吡啶基-4-氨基丙基类抑制剂的结合模式与活性，J. Med. Chem., 2014, 57。