Evaluation of the effect of captopril in the prevention of hand and foot syndrome and in patients with colon cancer

Intervention 1: Intervention group: Patients receiving 25 mg of captopril tablets daily for six weeks. Intervention 2: Control group: A placebo recipient who looks similar to Captopril and contains flour once a day for 6 weeks.
Primary outcome(s): Hand and foot syndrome. Timepoint: Every 3 weeks. Method of measurement: Physical examination.
Study Design: Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization of patients between the intervention and control groups is done using random allocation software. In this software, the total sample size and number of nodes are entered into the software. The output of Shalam software is a list that randomly distributes patients in groups 1 and 2. Patients are divided into two groups according to the time of referral according to the list of the mentioned group until the end of sampling, Blinding description: This study is performed in double blinds and patients and researchers are unaware of the type of drug received. Drugs are prepared in coded form in similar packages and are provided to the executor for prescription to patients. Outcome assessment is also done by someone who is not in the study.