Data from CRISPR screens in RH and PRU parasites.

NIAID Data Ecosystem2026-05-01 收录

CRISPRi筛选

寄生虫基因功能分析

数据链接：

https://figshare.com/articles/dataset/Data_from_CRISPR_screens_in_RH_and_PRU_parasites_/23698685 数据链接链接失效反馈

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资源简介：

Raw read counts, normalised counts, guide L2FCs, gene L2FCs, p-values, and DISCO scores. (XLSX)

创建时间：

2023-07-17

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

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Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.

干细胞鉴定

CRISPRi筛选

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms,

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TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron (CRISPR screen). TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron (CRISPR screen)

帕金森病细胞移植

CRISPRi筛选

First-in-human clinical trials illustrate the feasibility and translational potential of human pluripotent stem cell (hPSC)-based cell therapy in Parkinson’s disease (PD). However, a major unresolved

NIAID Data Ecosystem10

Genome-scale CRISPRi Perturb-seq on both unstimulated and stimulated Jurkat cells reveals regulators of human T-cell signaling

T细胞信号传导调控

CRISPRi筛选

The goal of the experiment is to identify genes involved in T-cell receptor (TCR) signaling and T-cell activation in human T cells. The Jurkat E6 cell line, engineered to express dCas9-KRAB and transd

NIAID Data Ecosystem20

Genes of CRISPR-Cas9 negative screening.

CRISPRi筛选

肿瘤免疫逃逸

We compared changes in sgRNA abundance between T24 cells challenged and unchallenged by CD8+ T cells, and then performed negative screening (p < 0.01, log2Fold change < −1.0, and good sgRNAs ≥ 5). (X

NIAID Data Ecosystem10

Data from CRISPR screens in RH and PRU parasites.

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