Next generation sequencing allows the comparison between Ectodysplasin knock-out mutant and wild-type murine lacrimal glands

We used RNAsequencing to reveal the differential gene expression in Ectodysplasin knock-out lacrimal gland compared to wild-type. We show that the mutant adult lacrimal gland differentially express specific genes, demonstrating a modifed maturation process when the Ectodysplasin gene is mutated. Overall design: Lacrimal glands were excised from adult mice (13wo). Three biological replicates were used for each condition (wild-type and mutant).