Whole genome sequencing study based on 84 pediatric B-cell precursor acute lymphoblastic leukemia

This whole genome sequencing (WGS) study is based on 84 pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL) patients diagnosed and treated at the Department of Pediatrics, Skåne University Hospital. The BCP ALL cases belong to the genetic subtypes high hyperdiploidy (HeH; <i>n</i> = 23), <i>ETV6</i>::<i>RUNX1</i> (<i>n</i> = 23), <i>TCF3</i>::<i>PBX1</i> (<i>n</i> = 9), and B-other (<i>n</i> = 29). The BCP ALL diagnostic and remission samples were sequenced at a “target sequencing dept” of 60x and 30x, respectively. The WGS data has been used to identify single nucleotide variants (SNVs) and insertions/deletions (indels) in coding and non-coding regions as well as structural variants (SVs), and copy number abnormalities (CNAs) targeting single genes or potentially causing fusion genes.<br><br>