Germline complex genomic rearrangements (CGRs) may involve one or more chromosomes and are thought to form through single cataclysmic events followed by the formation of multiple adjacent breakpoint j
Hydroxyurea (HU) is a widely used pharmacological therapy for sickle cell disease (SCD). However, replication stress caused by HU has been shown to inhibit premeiotic S-phase DNA, leading to reproduct
Microscopy images in the Figures and Supplemental Figures in Totsuka et al "Hybrid female infertility due to cohesin protection errors". Abstract Hybrid incompatibility can lead to lethality and steri
Aneuploidy, and especially the presence of unpaired chromosomal axes during meiosis, can cause infertility. However, it is not known if extra, unpaired autosomal chromosome segments acquire character
The adaptive value of sexual reproduction is still debated. A short-term disadvantage of asexual reproduction is loss of heterozygosity, which leads to the unmasking of recessive deleterious mutations