Vitreous of proliferative diabetic retinopathy patients

We identified lncRNA expression profiles in vitreous samples between proliferative diabetic retinopathy (PDR) patients and idiopathic macular hole (IMH) patients, and between PDR patients who had received preoperative anti-vascular endothelial growth factor (anti-VEGF) therapy and PDR patients who had received surgery alone. There had been the systemic expression differences in vitreous at the microarray level from PDR patients and IMH patients, and from PDR patients after anti-VEGF treatment and untreated PDR patients. This study was divided into 3 groups, which were group A consisting of IMH patients without diabetes, group B consisting of PDR patients pretreated with conbercept 3-7 days before surgery, and group C consisting of PDR patients who received surgery alone.