Dataset related to the manuscript: "Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-associated Pathophysiological Mechanism. The LEARNER Study."

Association between migraine and patent foramen ovale (PFO) has been documented. We aimed to investigate platelet activation, prothrombotic phenotype and oxidative stress status of migraineurs with PFO on 100mg/die aspirin, before and 6-months after PFO closure. Data show that, before PFO closure, expression of the classical platelet activation markers is comparable in patients and aspirin-treated-healthy subjects. Conversely, MHA-PFO patients display an increased prothrombotic phenotype (higher Tissue Factorpos -platelets and -microvesicles and thrombin generationeng potential), sustained by an altered oxidative stress status. This phenotype, which is more controlled by P2Y12-blockade than by aspirin, reverted after PFO closure together with a complete migraine remission