Molecular Analysis of Alliance A031201 Study

This is the first study examining the relationship between clonal hematopoiesis and clinical outcomes in prostate cancer patients. We used a targeted gene sequencing panel to identify patients in the A031201 clinical trial with and without clonal hematopoiesis. We found that clonal hematopoiesis did not affect overall or progression free survival in A031201 but was associated more adverse cardiac events.]]>
This study included patients in A031201 who consented to clinical correlative studies and provided peripheral blood samples. Please refer to Morris MJ, et al., cited below, for details on A031201.]]>