Skraup−Doebner−Von Miller Quinoline Synthesis Revisited: Reversal of the Regiochemistry for γ-Aryl-β,γ-unsaturated α-Ketoesters
收藏NIAID Data Ecosystem2026-03-06 收录
下载链接：
https://figshare.com/articles/dataset/Skraup_Doebner_Von_Miller_Quinoline_Synthesis_Revisited_Reversal_of_the_Regiochemistry_for_Aryl_unsaturated_Ketoesters/3064183
下载链接
链接失效反馈官方服务：
资源简介：
A reversal of the standard regiochemistry of the Skraup−Doebner−Von Miller quinoline synthesis was observed when
anilines were condensed with γ-aryl-β,γ-unsaturated α-ketoesters in refluxing TFA. The reaction is proposed to involve
1,2-addition of the anilines to γ-aryl-β,γ-unsaturated α-ketoesters to form Schiff's base adducts, followed by cyclization and oxidation. The products were unambiguously shown
to the 2-carboxy-4-arylquinolines by spectroscopy and X-ray
crystallographic analysis.
创建时间：
2016-02-29
