The positions of ZFBS and ZFBS-Morph overlaps in the build hg19 of the human genome

<p>Proteins that bind CpG containing sequences play central roles in numerous biological processes including the regulation of transcription and genomic imprinting.  Among these proteins, MLL1 and MLL2 bind a set of nonmethylation CpG-rich motifs, known as the MLL1 morphemes, in order to regulate transcription.  In contrast, ZFP57 binds a methylated hexameric DNA sequence.  ZFP57 functions in genomic imprinting.  In mammals, genomic imprinting results in the monoallelic expression of a subset of genes in parent-of-origin specific manner.  This complex process is regulated by the Imprinting Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs).  In the mouse genome, the known gDMRs include a set of composite DNA elements consisting of the ZFP57 binding site (ZFBS) overlapping a subset of the MLL1 morphemes.  It is thought that these composite elements (ZFBS-Morph overlaps) could be a key feature that drives the recruitment of the of DNMT3A andDNMT3L for processive methylation of the ICRs in one of the parental alleles.</p>

<p>This publication provides a text file that lists the positions of ZFBS and ZFBS-Morph overlaps in the build hg19 of the human genome.  The file is in a format (.bed) suitable for upload at the UCSC genome browser to create a custom track.  At the top right corner of the page, click on download to obtain and save a copy of the bed file.  Alternatively, click <a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&db=hg19&position=chr10:122,382-122,390%20&hgt.customText=https://purr.purdue.edu/publications/3208/serve?v=1" target="_blank"><em>here</em></a> to examine the listed positions directly at the UCSC genome browser.  If you observe anomalies on this page and if you encounter a problem with downloading the bed file, please contact bina@ purdue.edu</p>