Crystal structure of catalytic domain of TACE with hydroxamate inhibitor
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Crystal structure of catalytic domain of TACE with hydroxamate inhibitor Descriptor: (1R,2S)-N~2~-hydroxy-1-{4-[(2-phenylquinolin-4-yl)methoxy]benzyl}cyclopropane-1,2-dicarboxamide, ADAM 17, CITRIC ACID, ... Authors: Orth, P. Deposit date: 2008-08-20 Release date: 2008-10-21 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg.Med.Chem.Lett., 18, 2008
创建时间：
2008-08-20
