Source Data

Summary data used in the study as comma separated values (CSV)

Columns are:
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Demographics:
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subj: suject id
age: age in years
ses: session (pre=initial or post=follow-up appointment)
gender: Female=1 Male=2
handedness: Right=1, Left=2

Behavioral measures:
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YBOCS_Total: total YBOCS score
OBQ_Total: total OBQ score
MADRS_Total: total MADRS score
OCIR_Total: total OCIR score
Anx_Total: anxiety score of the HADS test
Dep_Total: depression score of the HADS test
FSIQ-4_Comp_Score: IQ score (only available at inital session (ses-pre)

Functional measures (Pearson's correlations):
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Acc_OFC: Nucleus Accumbens to orbitofrontal cortex functional connectivity
Acc_PFC: Nucleus Accumbens to dorsolateral prefrontal cortex functional connectivity
Acc_Put: Nucleus Accumbens to dorsal putamen functional connectivity
OFP_PFC: orbitofrontal cortex to dorsolateral prefrontal cortex functional connectivity
dPut_OFC: dorsal putamen to orbitofrontal cortex functional connectivity
dPut_PFC: dorsal putamen to dorsolateral prefrontal cortex functional connectivity

Simulations parameters:
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sim: simulation id (i.e. digital twin id)
distance: distance to empirical data in frontostriatal FC space
C_12: PFC to OFC coupling
C_13: NAcc to OFC coupling
C_21: OFC to PFC coupling
C_24: dPut to PFC coupling
C_31: OFC to NAcc coupling
C_34: dPut to NAcc coupling
C_42: PFC to dPut coupling
C_43: NAcc to dPut coupling
G: global coupling gain
eta_C_13: drift of the NAcc to OFC stochastic coupling
eta_C_24: drift of the dPut to PFC stochastic coupling
sigma: noise amplitude
sigma_C_13: volatility of the NAcc to OFC stochastic coupling
sigma_C_24: volatility of the dPut to PFC stochastic coupling

When z_ is appended before the parameter name, then the parameter value is z-score normalized based on the reference OCD parameters.

Efficacy measures
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dist : distance to healthy controls frontostriatal functional connectivity
n_test_params : number of targeted parameters of the virtual intervention
test_param : name of target parameters of the virtual intervention
tstat : Student T statistic of the distance to healthy controls
pval : p-value of the T-test
ustat : Mann-Whitney U statistic of the distance to healthy controls
upval : p-value of the Mann-Whitney U test
AUC : percentage of restoration achieved (calculated as ustat/(n1*n2))