ApoCanD

Apoptosis is a crucial cellular process, which determines the ultimate cell fate and has its own significance both in normal and diseased condition. Apoptosis process is inhibited in cancer cells, so that it can prolong its life without any regulatory check. To keep in mind the importance of this process, a database called "ApoCanD" has been created for the better understanding of role of apoptosis process in cancer. This database contains 82 proteins involved in various stages of apoptosis. It includes mutation status, expression level and copy number variation of proteins across the thousands of cancer cell lines and tumour samples.

细胞凋亡（Apoptosis）是一类至关重要的细胞生命过程，其决定了细胞的最终命运，在机体正常生理状态与病理病变条件下均具有不可替代的生物学意义。癌细胞会抑制细胞凋亡进程，使其得以脱离正常调控约束，实现无限存活。鉴于该过程的重要研究价值，研究人员构建了一款名为‘ApoCanD’的数据库，以助力学界更深入地解析细胞凋亡在癌症发生发展中的调控作用机制。该数据库收录了参与细胞凋亡不同阶段的82种蛋白质，涵盖数千株癌细胞系与肿瘤样本中这些蛋白质的突变状态、表达水平及拷贝数变异数据。

搜集汇总

背景与挑战

背景概述

ApoCanD是一个专注于细胞凋亡在癌症中作用的数据库，包含82个与凋亡过程相关的蛋白质。该数据集提供了这些蛋白质在大量癌细胞系和肿瘤样本中的突变状态、表达水平和拷贝数变异等多维度信息，用于支持癌症研究中对细胞凋亡机制的理解。