Structure of neuronal nitric oxide synthase D597N/M336V/Y706A triple mutant heme domain complexed with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy] pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine

Structure of neuronal nitric oxide synthase D597N/M336V/Y706A triple mutant heme domain complexed with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy] pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[(3R,4R)-4-(2-{[2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine, ACETATE ION, ... Authors: Delker, S.L, Li, H, Poulos, T.L. Deposit date: 2010-06-21 Release date: 2010-11-03 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives. J.Med.Chem., 53, 2010

神经元型一氧化氮合酶（neuronal nitric oxide synthase）D597N/M336V/Y706A三重突变体血红素结构域与6-{(3'R,4'R)-3'-[2''-(3'''-氟苯乙氨基)乙氧基]吡咯烷-4'-基}甲基}-4-甲基吡啶-2-胺结合的复合物结构。
描述项：5,6,7,8-四氢生物蝶呤（5,6,7,8-TETRAHYDROBIOPTERIN）、6-{[(3R,4R)-4-(2-{[2-(3-氟苯基)乙基]氨基}乙氧基)吡咯烷-3-基]甲基}-4-甲基吡啶-2-胺、乙酸根离子（ACETATE ION）……
作者：Delker, S.L、Li, H、Poulos, T.L.
提交日期：2010-06-21
发布日期：2010-11-03
最后修改日期：2024-02-21
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.2 Å。
引用文献：《通过设计合成吡咯烷甲基2-氨基吡啶衍生物探索神经元型一氧化氮合酶活性位点》，《J.Med.Chem.》，53卷，2010年。