Human JNK2 bound to covalent inhibitor YL2056

Human JNK2 bound to covalent inhibitor YL2056 Descriptor: 4-(dimethylamino)-N-{4-[(3S)-3-({4-[(8R)-2-phenylpyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}amino)pyrrolidine-1-carbonyl]phenyl}butanamide, Mitogen-activated protein kinase 9 Authors: Li, L, Gurbani, D, Westover, K.D. Deposit date: 2022-09-23 Release date: 2023-06-28 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.072 Å) Cite: Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J.Med.Chem., 66, 2023结合共价抑制剂YL2056的人源JNK2。标识符：4-(二甲基氨基)-N-{4-[(3S)-3-({4-[(8R)-2-苯基吡唑并[1,5-a]吡啶-3-基]嘧啶-2-基}氨基)吡咯烷-1-羰基]苯基}丁酰胺，该蛋白为丝裂原活化蛋白激酶9（Mitogen-activated protein kinase 9）。作者：Li, L、Gurbani, D、Westover, K.D. 存储日期：2022-09-23，发布日期：2023-06-28，最后修改日期：2024-11-13。实验方法：X射线衍射法（分辨率2.072埃）。引用文献：《对JNK1具有选择性的c-Jun氨基末端激酶（JNK）2/3共价抑制剂的开发》，《药物化学杂志》（J.Med.Chem.），66卷，2023年。