STAG2 encodes a cohesin component and is frequently mutated in myeloid neoplasms, showing highly significant co-mutation patterns with other drivers, including RUNX1. However, the molecular basis of c

NIAID Data Ecosystem30

Regulation of cohesin-mediated chromosome structure by PDS5 in mammals [RNA-seq]. Regulation of cohesin-mediated chromosome structure by PDS5 in mammals [RNA-seq]

染色质环化

三维基因组学

Cohesin regulates sister chromatids cohesion but also contributes to chromosome folding by promoting the formation of chromatin loops, a process proposed to be mediated by loop extrusion. PDS5 plays a

NIAID Data Ecosystem20

FOXF1 promoter-putative enhancer chromatin looping

FOXF1基因调控

染色质环化

To determine if there is a physical interaction between the FOXF1 promoter and putative enhancer sequences ~250kb upstream of the promoter chromosome conformation capture-on-chip (4C) analysis was per

NIAID Data Ecosystem40

CTCF binding polarity determines chromatin looping [ChIP-seq]. Mus musculus

CTCF结合极性分析

染色质环化

CTCF binding polarity determines chromatin looping Overall design: CTCF ChIPseq was performed in E14 embryonic stem cells and neural precursor cells

NIAID Data Ecosystem30