A New Method for High-Yield Cyclopalladation of Primary and Secondary Amines. Atom-Efficient Open-to-Air Inexpensive Synthesis of Buchwald-Type Precatalysts
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https://figshare.com/articles/dataset/A_New_Method_for_High_Yield_Cyclopalladation_of_Primary_and_Secondary_Amines_Atom_Efficient_Open_to_Air_Inexpensive_Synthesis_of_Buchwald_Type_Precatalysts/2615509
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资源简介：
A new method for high-yield cyclopalladation of primary and secondary
amines involving the corresponding ammonium triflates, instead of
the amines generally employed, is reported. The method is applied
for the synthesis of Buchwald-type precatalysts [Pd(C,N-C6H4CH2CH(R′)NHR-2)X(phosphine)]
that can be easily prepared by reaction of Pd(OAc)2, 1
equiv of the ammonium triflate [PhCH2CH(R′)NH2R]OTf, and an excess of NaX and then treating the resulting
complexes [Pd2(C,N-C6H4CH2CH(R′)NHR-2)2(μ-X)2] with the appropriate phosphine. This new
method has several advantages over Buchwald's reported synthesis.
创建时间：
2016-02-23
