Unusual organization of the human T-cell receptor beta-chain gene complex is linked to recombination hotspots.
收藏PubMed Central1993-06-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC46646/
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资源简介：
Two rare Sfi I polymorphisms of 360 kb and 280 kb present within the human T-cell antigen receptor beta-chain gene complex were revealed by pulsed-field gel electrophoresis. They represent allelic variants of the polymorphic 330- and 300-kb Sfi I fragments previously described. The 360-kb polymorphism results from duplication of the 30-kb DNA fragment responsible for the 330/300-kb insertion/deletion-related polymorphism. The 280-kb polymorphism results from a 20-kb deletion from the 300-kb SfiI allele. The rare polymorphisms also map on either side of a Sal I site located near a recombination hotspot, suggesting that germline duplications and deletions arose from nonhomologous crossover events. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-06-01
