RNA-sequencing of serial biopsies from 3 patients treated with Capivasertib (AZD5363)
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First line treatment with AKT inhibitors combined with paclitaxel improves outcomes of metastatic TNBC, especially in tumors that harbor mutations in PTEN/PIK3CA/AKT1. In this work, we refine the composite response biomarker to AZD5363 in this setting, which is relevant to inform the clinical development of these drugs. 9 biospies from 3 patients pre-, on- and post- therapy
创建时间：
2020-09-30
