Supplementary data on confocal imaging of Porphyromonas gingivalis release of polyphosphates and fibrin formation

The hypothesis was that Porphyromonas gingivalis by secreting gingipains or polyphosphates could initiate blood coagulation and thereby contribute to fibrin deposition in gingival tissue which in turn promotes chronic inflammation. Chronic inflammation in gingival tissue eventually leads to bone degradation and loss of tooth support, known as periodontitis. The results show that P. gingivalis initiate coagulation by means of gingipains as well as polyphosphates.
Supplementary data on confocal imaging of P. gingivalis release of polyphosphates and fibrin formation; mages and microscopy movies.

本研究假设牙龈卟啉单胞菌通过分泌牙龈蛋白酶或多磷酸盐，能够启动血液凝固过程，从而促进牙龈组织中纤维蛋白的沉积。这一过程进而加剧了慢性炎症。牙龈组织的慢性炎症最终导致骨质的降解和牙齿支持的丧失，即所谓的牙周炎。研究结果表明，牙龈卟啉单胞菌通过牙龈蛋白酶以及多磷酸盐的途径启动了凝固过程。此外，补充数据包括对牙龈卟啉单胞菌释放多磷酸盐和纤维蛋白形成过程的共聚焦成像；图像及显微镜动态电影。