Candida albicans interaction with intestinal epithelial cells

To characterize the interaction of Candida albicans with intestinal epithelial cells (C2BBe1) from early fungal adhesion to invasion (up to 6 h) and the late translocation and damage phase (12 -24 h), we conducted dual RNA-sequencing of C. albicans-infected C2BBe1 cells over a 24 h time course, with sampling at 0 h, 45 min, 3 h, 6 h, 12 h, and 24 h. Overall design: Gene expression profiling analysis of RNA-seq data comparing C2BBe1 cells infected with Candida albicans with C2BBe1 or C. albicans cells cultured alone, with the aim to identify infection-specific gene expression.