The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven b

NIAID Data Ecosystem50

Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways

肿瘤转化机制

信号通路交互研究

Hormone therapy resistance and the ensuing aggressive tumor progression present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy upon inhibition o

NIAID Data Ecosystem30

Loss of Heterozygosity at the Ink4a/Arf Locus Facilitates Abelson Virus Transformation of Pre-B Cells

肿瘤转化机制

前B细胞恶性进展

In many tumor systems, analysis of cells for loss of heterozygosity (LOH) has helped to clarify the role of tumor suppressor genes in oncogenesis. Two important tumor suppressor genes, p53 and the Ink

PubMed Central80

The cellular origin and malignant transformation of Waldenström's Macroglobulinemia [gene expression]. Homo sapiens

B细胞淋巴瘤分子病理学

肿瘤转化机制

Although information on the molecular pathogenesis of Waldenström’s Macroglobulinemia (WM) has greatly improved in recent years, the exact cellular origin and the mechanisms behind WM transformation f

NIAID Data Ecosystem50

RNA sequencing and small RNA sequencing of micro vesicles secreted by RPMI 8226 cell line

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