Effect of Pak4 ablation on transcriptome in liver of fasted mice

Hepatic ketogenesis is crucial for energy homeostasis in a fast state, whereas defective ketogenesis is associated with various diseases. We explored the role of PAK4, an oncoprotein, in ketogenesis. To investigate the molecular basis, we carried out RNA-sequencing analysis using littermate WT and hepatocyte-specific Pak4 KO mice in fasted conditions. Examination of RNA profile in liver of WT and hepatocyte-specific Pak4 KO mice in 24 h fasted condition.