Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-hydroxynaphthalene-2-carboxylic acid

Crystal structure of M. tuberculosis InhA in complex with NAD+ and 3-hydroxynaphthalene-2-carboxylic acid Descriptor: 3-hydroxynaphthalene-2-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Enoyl-[acyl-carrier-protein] reductase [NADH], ... Authors: Mendes, V, Sabbah, M, Coyne, A.G, Abell, C, Blundell, T.L. Deposit date: 2019-09-03 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Fragment-Based Design ofMycobacterium tuberculosisInhA Inhibitors. J.Med.Chem., 63, 2020结核分枝杆菌（M. tuberculosis）InhA蛋白与烟酰胺腺嘌呤二核苷酸（NAD+）及3-羟基萘-2-羧酸形成复合物的晶体结构 描述项：3-羟基萘-2-羧酸、4-(2-羟乙基)-1-哌嗪乙磺酸、烯酰-[酰基载体蛋白]还原酶[NADH]…… 作者：Mendes V、Sabbah M、Coyne A.G、Abell C、Blundell T.L. 提交日期：2019-09-03 发布日期：2020-04-22 最后修改日期：2024-01-24 实验方法：X射线衍射（分辨率1.75 Å） 引用文献：《基于片段的结核分枝杆菌InhA抑制剂设计》，《药物化学杂志》（J.Med.Chem.），第63卷，2020年