PI3K inhibitor resistance

NIAID Data Ecosystem2026-05-02 收录

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https://www.ncbi.nlm.nih.gov/sra/SRP514818

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We analyzed the differential genes between PI3K inhibitor resistant strains and their parents

创建时间：

2024-12-31

Analysis of PI3K inhibitor resistance in HNSCC

Illumina total RNA sequencing libraries run on a NovaSeq6000 with a 300 cycle run. RNA isolated from head and neck squamous cell carcinoma cell line UM-SCC-108 treated with DMSO, 1uM Pictilisib, 0.5uM

NIAID Data Ecosystem20

PI3K inhibitors block PI3K catalytic activity

A variety of inhibitors capable of blocking the phosphoinositide kinase activity of PI3K have been developed. These inhibitors display differential selectivity and inhibit kinase activity of their sub

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Selective PI3K beta inhibitor bound to PI3K delta

Selective PI3K beta inhibitor bound to PI3K delta Descriptor: 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine, Phosphatidylinositol 4,

Protein Data Bank Japan2024-03-13 更新30

Analysis of PI3K inhibitor resistance in HNSCC

NIAID Data Ecosystem20

Crystal structure of PI3K alpha with PI3K delta inhibitor

Crystal structure of PI3K alpha with PI3K delta inhibitor Descriptor: 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile, Phosphatidylinositol 3-kinase reg

Protein Data Bank Japan2025-04-09 更新40