Crystal structure of spleen tyrosine kinase complexed with R406

Crystal structure of spleen tyrosine kinase complexed with R406 Descriptor: 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, Tyrosine-protein kinase SYK Authors: Kuglstatter, A, Villasenor, A.G. Deposit date: 2009-01-07 Release date: 2009-03-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. Chem.Biol.Drug Des., 73, 2009与R406复合的脾酪氨酸激酶（spleen tyrosine kinase）晶体结构 描述物：6-({5-氟-2-[(3,4,5-三甲氧基苯基)氨基]嘧啶-4-基}氨基)-2,2-二甲基-2H-吡啶并[3,2-b][1,4]恶嗪-3(4H)-酮，酪氨酸蛋白激酶SYK（Tyrosine-protein kinase SYK） 作者：Kuglstatter, A、Villasenor, A.G. 存放日期：2009-01-07 发布日期：2009-03-10 最后修改日期：2023-09-06 实验方法：X射线衍射（分辨率2.1 Å） 引用文献：《基于三种抑制剂复合物晶体学分析设计强效脾酪氨酸激酶抑制剂的结构洞察》，Chem. Biol. Drug Des., 73, 2009