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The discrepancy between local measurements of the Hubble constant (H0) and the value inferred from observations of the CMB may be our strongest indication of physics beyond a Lambda-CDM cosmological model. Direct comma distance-ladder measurements of the H0 rely primarily on Cepheids and the Tip of the Red Giant Branch (TRGB) to calibrate the luminosity of Type Ia supernovae (SN Ia). Here we propose an independent approach using Mira variables. Miras can check existing Cepheid and TRGB measurements while extending the distance ladder in the era of infrared space missions such as JWST and Roman Space Telescope comma which will have difficulty discovering Cepheids. Miras are pulsating variable stars that follow tight (virgul0.12 mag scatter) Period-Luminosity Relations (PLRs) in the near-infrared (NIR). Short-period Miras (P < 400 d) have NIR luminosities up to 2 mag brighter than TRGB and are a ubiquitous older population that have already been used to calibrate H0 with 5% uncertainty. Long-period Miras (P > 400 d) are highly luminous and follow a different PLR from short-period Miras. We will (1) obtain a new distance measurement to this galaxy using short-period Miras comma resulting in a sub-3% calibration of H0 with Miras when combined with existing Mira-SN Ia hosts (2) discover long- period Miras with HST for the first time (3) cross-correlate long-period variables discovered in HST with Spitzer IR observations. To do this comma we propose to obtain 5 epochs of near-infrared observation in M101 comma to study Miras in the field of SN Ia 2011fe. Combining these with archival observations of the late-time lightcurve of SN 2011fe results in virgul10 epochs of observation with a baseline of virgul3000 days.