Advanced glycation end products promote the metastasis of colorectal cancer cells via centrosome amplification mediated by KLF5-CEP57L1 axis

Emerging evidence suggests that diabetes and centrosome amplification (CA) are associated with metastasis and in vitro invasion of cancer cells, respectively. We have reported that diabetes promotes CA; thus, we sought to determine whether CA may serve as a biological link between diabetes and metastasis. Our study demonstrated that advanced glycation end products (AGEs) in vitro simultaneously promoted CA, migration and invasion of HCT116 colorectal cancer cells, with higher levels of CA in migrated cells. Herein, we provided the original western blot and transcriptomic profling results.