Catalytic Asymmetric Friedel–Crafts/Protonation of Nitroalkenes and N-Heteroaromatics

The catalytic asymmetric Friedel–Crafts/protonation of indoles and pyrroles with α-substituted nitroalkenes to give the corresponding adducts in a highly anti-selective manner was achieved by an imidazoline–aminophenol (L2)–Cu complex. The anti-adducts could be successfully transformed to biochemically important α-substituted β-heteroarylalkylamines.