Summary of lag times of SOD1 fibrillization for seeded reactions with pre-formed fibrils of SOD1 mutants into wtSOD1 protein and with spinal cord homogenates into G93A and wtSOD1 proteins.

Fmax = average maximum fluorescence (arbitrary unit, a.u.), T0.5 = observed time at transition mid-point (hrs), lag time = incubation duration prior to initiation of fibrillization (hrs), τ = 1/propagation rate of fibril growth (hrs), tgSOD1G93A = transgenic SOD1 mice carrying the G93A mutation, tgSOD1wtSOD1 = transgenic wtSOD1 overexpressor mice; n/a = not available. Data shown are average values from 4 to 10 replicates (± SEM) pooled from 2 to 3 independent assays.