Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells. Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells

Our study reveals that while antiestrogen therapies effectively limit tumor growth in ER-positive breast cancers, they also trigger a transcriptional program that favors immune evasion. Overall design: Study of differential gene expression among wt and CSK k.o. MCF-7 breast cancer cells cultured in DMEM or Fulvestrant