Additional file 1 of Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans

Additional file 1: Table S1. Association Results Top Hits <1.0E−06 in Any Model. Table S2. Association Results Top Hits<1.0E−04 in Any Model. Table S3a. Replication Look-up in COMPASS and MEGASTROKE based on Supplementary Table 1. Table S3b. Replication Look-up in COMPASS and MEGASTROKE based on Supplementary Table 2. Table S4a. Replication Status of Variants previously associated with Stroke in COMPASS and Comparison with SIREN stroke. Table S4b. Replication Status of Variants previously associated with Stroke in MEGASTROKE and Comparison with SIREN stroke. Table S5a. Replication of COMPASS significant results in SIREN stroke types. Table S5b. Replication of MEGASTROKE significant results in SIREN stroke types. Table S5c. COMPASS study’s significant SNPs replication in SIREN for stroke subtypes. Table S6. Metasoft meta-analysis results driven by Meta-analysis P-value. Table S7. Meta-Analysis Results from MANTRA. Table S8a. Fine mapping of AADACL2 gene region. Table S8b. Posterior Probabilities for SNPs in the AADACL2 fine-mapping regions of gene. Table S9a. Fine mapping of MIR4458HG gene region. Table S9b. Posterior Probabilities for SNPs in the MIR4458HG fine-mapping regions of gene. Table S10a. FUMA GENE2SNP MAGMA differentially expressed genes (DEG) from GTEx v8 data for specific tissue type. Table S10b. FUMA GENE2FUNC MAGMA differentially expressed genes (DEG) from GTEx v8 data for specific tissue types. Table S11. FUMA GENE2SNP's positional, eQTL or chromatin interaction mapping results on functionally relevant SNPs and GWAS top-hit SNPs. Table S12. FUMA SNP2GENE Interactions showing eQTL and Chromatin Interaction statistics based on functionally relevant SNPs and GWAS top-hit SNP with P-value < 1E-4 along with Gene and Protein Annotation for selected Tissues. Table S13a. Genetic loci associated with stroke by ancestry. Table S13b. Functional annotations of genetic loci associated with stroke in MEGASTROKE. Table S13c. Functional annotations of genetic loci associated with stroke in COMPASS. Table S13d. Functional annotations of genetic loci associated with stroke in GIGASTROKE.