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Expression data from Bone marrow and Fetal liver Lineage-c-Kit+Sca-1+ (LSK) cells

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE69760
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Loss of polycomb-group gene Ezh2 causes activation of fetal gene signature in adult mouse bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs). Ezh2 directly represses fetal-specific let-7 target genes, including Lin28, thereby cooperates with let-7 microRNAs in silencing fetal gene signature in BM HSPCs. We purified Lineage-Sca-1+c-Kit+ (LSK) HSPCs from E14.5 FL and adult BM and subjected them to microarray analysis.
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2018-02-02
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