Effect of lactoferrin on hepatic steatosis scores.

Following eight weeks of lactoferrin administration (0, 50, 100, and 200 mg/kg), the control group had a significantly higher histopathological steatosis score than the naïve group (###P<0.001). The lactoferrin-treated groups had significantly lower steatosis scores than the control group (**P<0.01, ***P<0.001). Data are presented as means and were analyzed with non-parametric statistics followed by the Mann–Whitney U-test to compare group differences. Grade designations of the histological findings are: (−, 0) normal, (+, 1) slight, (++, 2) moderate, and (+++, 3) severe steatosis. Each value represents the number of animals that showed a change in grade during the experimental period.