The bile of 5-Fluorouracil (100 mg/kg, i.v.) pharmacokinetics in rats after whole pelvic irradiation with and without 0.5 and 2 Gy.

AUC: area under the plasma concentration vs. time curve; t1/2: terminal elimination phase half-life; Cmax: maximum observed plasma concentration; MRT: mean residence time; CL: total plasma clearance; Vss: volume of distribution at steady state.*The mean difference is significant at the 0.05 level in comparison to the control group.†The mean difference is significant at the 0.05 level between the 0.5 and 2 Gy groups.