The Roles and Underlying Mechanisms of Histone Deacetylases in Alcohol-Associated Liver Disease

This dataset consists of scientific schematic diagrams compiled and drawn by the author to illustrate the roles and mechanisms of histone deacetylases (HDACs) in alcohol-associated liver disease (ALD). It mainly includes two components: a mechanistic diagram showing the protective roles of HDACs and a mechanistic diagram showing the non-protective roles of HDACs. Both figures were independently created by the author on April 26, 2025, using Microsoft Visio. Based on prior literature review, information extraction, logical synthesis, and mechanistic integration, the dataset systematically visualizes the HDAC-related molecules, signaling pathways, and regulatory relationships involved in the onset and progression of ALD. The dataset was generated through the following process: first, relevant Chinese and English literature on the research topic was systematically collected and reviewed, and key information involving HDAC subtypes, lipid metabolism, inflammatory responses, oxidative stress, mitochondrial dysfunction, autophagy, cellular injury, and histopathological alterations was extracted; second, the molecular names, signaling pathway nodes, regulatory directions, and functional properties reported in different studies were manually screened, classified, consolidated, and logically verified to construct separate mechanistic frameworks for protective and non-protective effects; finally, Microsoft Visio was used to standardize the layout of nodes, connecting lines, arrows, colors, and legends, resulting in the final figures. The equipment used in generating the dataset was a personal computer, and the main software tool was Microsoft Visio. If editable source files are included in the submission, it is recommended that they be opened and edited using Microsoft Visio or compatible software; the software can be obtained from the official Microsoft website.The content of this dataset belongs to the category of mechanistic schematic graphic data and does not involve raw observational processes such as field sampling, continuous monitoring, remote sensing inversion, or direct output from experimental instruments. Therefore, it does not contain information in the conventional sense of geographic coordinates, spatial extent, spatial resolution, or temporal resolution. The time information involved in the dataset mainly refers to the completion date of the figures, namely April 26, 2025. The mechanistic relationships presented in the figures are derived from publicly published literature reviewed and organized by the author prior to drawing, and they reflect a synthesized understanding of the topic up to the time of figure preparation rather than raw measurements from a specific time point or a continuous time-series dataset. In terms of spatial information, this dataset is not associated with any specific geographic region, sampling site, or experimental location, and therefore does not contain spatial attributes; spatial resolution is not applicable.This dataset mainly consists of image files and/or editable drawing files. The image files are the final presentation versions and mainly include the schematic diagram “Protective Roles and Mechanisms of Histone Deacetylases in ALD” and the schematic diagram “Non-protective Roles and Mechanisms of Histone Deacetylases in ALD,” which are suitable for viewing, manuscript layout, academic presentations, and research dissemination. If Visio source files are also included, they contain the editable project files corresponding to the figures, facilitating later modification of node labels, line styles, legends, and layout design. This dataset is not tabular in nature and therefore does not involve record counts, row labels, column labels, or measurement units. The text in each node mainly represents the names of relevant proteins, molecules, pathways, or biological processes, while arrows and connecting lines indicate promoting, inhibitory, associative, or regulatory relationships. The meanings of solid lines, dashed lines, and other symbols are defined by the legends within the figures.This dataset is a form of secondary processed data generated through the author’s manual organization, synthesis, and drawing based on publicly available literature, and therefore it does not involve missing values in the conventional sense of raw observational data. However, it should be noted that the content shown in the figures is a refined summary and abstraction of existing research findings and may not exhaustively cover all mechanisms reported in this field. For some relationships, because different studies vary in experimental subjects, model conditions, research methods, and levels of evidence, the graphical presentation may involve a certain degree of generalization and simplification. Accordingly, this dataset may contain information abstraction errors arising from the scope of literature selection, the author’s interpretation, the method of mechanistic integration, and the graphical representation approach. These may mainly be reflected in the simplification of complex molecular events into single nodes or linear relationships, and in the generalized presentation of mechanistic conclusions that have not yet been fully unified across studies. In addition, for the sake of improving figure readability, node positions and connecting structures may have been adjusted during layout design in a manner that does not carry biological spatial meaning. These characteristics do not affect the use of the dataset as material for mechanistic synthesis, graphical presentation, and academic communication; however, when using it for further quantitative analysis, experimental design, or clinical inference, users are advised to verify the relevant mechanistic information against the original references.Overall, this dataset belongs to the category of unstructured graphic data. Its core value lies in the systematic synthesis and visualization of the potentially protective and non-protective mechanisms of HDACs in ALD, and it may serve as a useful reference for manuscript preparation, grant applications, academic presentations, and subsequent mechanistic studies. If the submitted files include relatively specialized formats such as .vsdx, these formats are mainly intended to be opened and edited using Microsoft Visio. If the submitted files are in common image formats such as PNG, JPG, or TIFF, they can be directly viewed and used in standard image viewers, office software, and typesetting software.