Global protein data of proteomics of spleen infected by Babesia microti

Babesia is a kind of protozoa parasitic in the red blood cells of some vertebrates. Some species of Babesia can cause human and animal co-infection and do great harm. As the largest immune organ in mammals, spleen plays an important role in resisting Babesia infection. Although the spleen infected by Babesia is seriously damaged, it still initiates the immunomodulatory response actively. In order to further explore the molecular mechanism of immune regulation and self-repair of spleen in response to infection, DIA quantitative proteomics was used to analyze the changes of total protein expression and phosphorylation modification in spleen tissue of mice infected with Babesia microti, so as to explore the self-regulation mechanism of spleen in the process of injury and repair. It provides an important basis for the diagnosis and treatment of babesiosis.