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D-2-Hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

ChEBI2014-03-01 更新2026-07-21 收录

代谢疾病机制

小鼠疾病模型

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-54838 数据链接链接失效反馈

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D-2-Hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

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2014-03-01

代谢疾病机制

基因敲除模型

Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Additionally, obesity and type 2 diabetes are characterized by chroni

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Additional file 6: Table S5. of Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver

代谢疾病机制

营养基因组学

Genotype-by-diet interactions affecting gene expression. (XLSX 23 kb)

Figshare2016-12-15 更新50

Validated urine metabolites that were differentially abundant in RM as compared to CM in Atm-KO and WT mice.

代谢组学分析

小鼠疾病模型

Validated urine metabolites that were differentially abundant in RM as compared to CM in Atm-KO and WT mice.

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The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

非酒精性脂肪性肝炎遗传易感性

小鼠疾病模型

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DataSheet_3_Cyto-IL-15 synergizes with the STING agonist ADU-S100 to eliminate prostate tumors and confer durable immunity in mouse models.xlsx

前列腺癌免疫治疗

小鼠疾病模型

IntroductionProstate cancer is one of the most commonly diagnosed malignancies in men with high mortality rates. Despite the recent therapeutic advances, such as immunotherapies, survival of patients

NIAID Data Ecosystem40

D-2-Hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

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