Aberrant M1 polarization of macrophages in Behcet's disease

Macrophages are key inflammatory immune cells in Behcet's disease (BD) and BD serum may contribute to macrophages' hyperactivation in BD. To further investigate the role of BD serum on the phenotypes and functions of macrophages, we performed next generation sequencing-based genome-wide transcriptional profiling on BD serum or healthy control (HC) serum treated macropahges. Overall design: Transcriptional profiling of BD serum treated macropahges (n=4) and HC serum treated macropahges (n=4).