Farnesyltransferase complex with tetrahydropyridine inhibitors

Farnesyltransferase complex with tetrahydropyridine inhibitors Descriptor: 1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... Authors: Gwaltney II, S.L, O'Conner, S.J, Nelson, L.T, Sullivan, G.M, Imade, H, Wang, W, Hasvold, L, Li, Q, Cohen, J, Gu, W.Z. Deposit date: 2002-11-22 Release date: 2003-01-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency. Bioorg.Med.Chem.Lett., 13, 2003法尼基转移酶（farnesyltransferase）复合物与四氢吡啶类抑制剂 描述：1-{2-[3-(4-氰基苄基)-3H-咪唑-4-基]乙酰基}-5-萘-1-基-1,2,3,6-四氢吡啶-4-甲腈、α-羟基法尼基膦酸、蛋白法尼基转移酶α亚基，…… 作者：Gwaltney II, S.L.、O'Conner, S.J.、Nelson, L.T.、Sullivan, G.M.、Imade, H.、Wang, W.、Hasvold, L.、Li, Q.、Cohen, J.、Gu, W.Z. 存入日期：2002-11-22 发布日期：2003-01-07 最后修改日期：2024-02-14 实验方法：X射线衍射（3.2 Å） 引用文献：芳基四氢吡啶类法尼基转移酶抑制剂：具有更佳细胞活性的生物可利用类似物。《Bioorg.Med.Chem.Lett.》，第13卷，2003年