Longitudinal Changes in Metabolic Parameters, Body Composition, and Carotid Intima-Media Thickness among People Living with HIV Receiving Antiretroviral Therapy

This dataset accompanies the manuscript “Progression of carotid intima-media thickness, visceral fat accumulation and metabolic derangement in HIV-Positive Patients on Antiretroviral Therapy” submitted to PLOS ONE.The study prospectively followed a cohort of 132 HIV-positive adults initiating antiretroviral therapy (ART) at Siriraj Hospital, Thailand, with assessments conducted at baseline, 12, 24, and 36 months.Key domains included: Metabolic and renal parameters: weight, waist and hip circumference, fasting glucose, HbA1c, lipid profile (total cholesterol, triglycerides, HDL, LDL), creatinine, and estimated glomerular filtration rate (eGFR). Body composition: bioelectrical impedance analysis (BIA; fat mass, body fat percentage, visceral adipose tissue [VAT]) and dual-energy X-ray absorptiometry (DXA; fat mass, body fat percentage, android-to-gynoid fat ratio). Carotid intima-media thickness (cIMT): ultrasound-derived measurements of common carotid arteries (proximal, mid, distal), bifurcation, and internal carotid arteries bilaterally. Immunological and virological outcomes: CD4 cell counts and proportion of participants with HIV RNA suppression (Data structure (Supporting Information files):S1 Table. Baseline characteristics of study participants (individual-level de-identified data).S2 Table. Anthropometric, metabolic, and renal parameters over 36 months (summary statistics).S3 Table. Body composition by BIA and DXA during follow-up.S4 Table. Carotid intima-media thickness measurements over 36 months.S5 Table. Immunological and virological outcomes (CD4, HIV RNA suppression).S6 Table. Antiretroviral drug class exposure during follow-up.Ethics:All data have been de-identified to protect participant privacy. The study protocol was approved by the Institutional Review Board of the Faculty of Medicine Siriraj Hospital, Mahidol University.Potential reuse:These data may be useful for researchers studying HIV-associated metabolic complications, cardiovascular risk assessment, long-term effects of ART, and for meta-analyses in the fields of infectious diseases, endocrinology, and cardiovascular epidemiology.