Apoptosis
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ndexbio.org/viewer/networks/3ab7dfe7-9e16-11eb-9e72-0ac135e8bacf
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The Apoptosis network describes causal mechanisms in several different signaling pathways that are involved in the induction of apoptosis in response to environmental cues. The pathways include ER stress signaling, particularly the PERK-eIF2alpha-ATF4-CHOP pathway, MAPK components that regulate the pro-apoptotic proteins (Bad,Bax, Bim) via PI3K/AKT and JNK pathways, NFkB signaling which induces downstream expressions of anti-apoptotic proteins, PKC-mediated apoptosis, and activation of TNFR1 and Fas receptor leading to downstream signaling of caspase-8. The network also characterizes the transcriptional role of TP53 in apoptosis through the presence of its downstream anti-apoptotic and pro-apoptotic targets. \nReviewed during Jamboree2014
创建时间：
2021-04-15
